Methylamine → N-methyl-1-(4-nitrophenyl)methanamine

HRID 430959

반응식

HRID 430959 반응식
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Br)=[CH:6][CH:5]=1)([O-:3])=[O:2].[CH3:12][NH2:13]>C(#N)C.[Cl-].[Na+].O>[CH3:12][NH:13][CH2:8][C:7]1[CH:10]=[CH:11][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1

참가 물질

5

반응물 2

HCID 6329MethylamineHCID 660114-Nitrobenzyl bromide

생성물 1

HCID 409440N-methyl-1-(4-nitrophenyl)methanamine수율 97.2%

시약·촉매·용매 2

HCID 6342Acetonitrile용매2회HCID 57417360Sodium chloride; water용매

실험 절차

A solution of p-nitrobenzylbromide (5.40 g, 25 mmol) in acetonitrile (60 ml) is added dropwise to a stirred solution of aqueous methylamine (65 mL, 40 wt. %, 0.75 mol) in acetonitrile (50 mL) at 0°. After stirring an additional 15 minutes, the solution is poured into brine and extracted 2× with dichloromethane. The combined organic layers are washed with brine, dried over sodium sulfate, filtered, and concentrated in vacuo to give 4-(methylaminomethyl)nitrobenzene (4.04g).

후처리

  1. extractionextracted 2× with dichloromethane
  2. washThe combined organic layers are washed with brine
  3. dry with materialdried over sodium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-34d76e8d03e045edb910352de3dfe344
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06656941B2

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