N-Methylbenzylamine → 4-(N-benzyl-N-methyl-amino)-dihydro-furan-2-one

HRID 431018

반응식

HRID 431018 반응식
[CH3:1][NH:2][CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[O:10]1[CH2:14][CH:13]=[CH:12][C:11]1=[O:15]>C(Cl)Cl>[CH2:3]([N:2]([CH:13]1[CH2:14][O:10][C:11](=[O:15])[CH2:12]1)[CH3:1])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 7669N-MethylbenzylamineHCID 103412(5H)-Furanone

생성물 1

HCID 699551354-(N-benzyl-N-methyl-amino)-dihydro-furan-2-one

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

23.20 ml of N-methylbenzylamine are added to 15.00 g of 5H-furan-2-one in 150 ml methylene chloride. The reaction mixture is stirred for about 48 hours at ambient temperature. For working up the reaction mixture is concentrated by evaporation and chromatographed in batches over a silica gel column with ethyl acetate/petroleum ether (3:1) as eluant. The desired product is obtained as a yellowish oil.

후처리

  1. concentrationis concentrated by evaporation
  2. customchromatographed in batches over a silica gel column with ethyl acetate/petroleum ether (3:1) as eluant

출처 및 근거

ORD 기록
ord-af25213858bc4f09848fe3319cfce942
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06656946B2

연결된 노트

불러오는 중…