Hydrochloric Acid → HCID 20607351, 화합물

HRID 431027노트

반응식

HRID 431027 반응식
[ClH:1].C(OC([NH:9][C@H:10]1[C@@H:14]([CH2:15][F:16])[CH2:13][NH:12][CH2:11]1)=O)(C)(C)C>O>[ClH:1].[ClH:1].[NH2:9][C@H:10]1[C@@H:14]([CH2:15][F:16])[CH2:13][NH:12][CH2:11]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 10513010HCID 10513010, 화합물

생성물 1

HCID 20607351HCID 20607351, 화합물수율 75%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Concentrated hydrochloric acid (1 ml) was added to 3-(S)-tert-butoxycarbonylamino-4-(S)-fluoromethylpyrrolidine (441 mg, 2.02 mmol) which was cooled in an ice bath, and the mixture was stirred for 10 minutes. The reaction solution was mixed with water (5 ml) and washed with dichloromethane (5 ml×3) and diethyl ether (5 ml×1). The aqueous layer was concentrated under a reduced pressure, and the resulting residue was purified by its recrystallization from methanol to give 288 mg (75%) of the title compound in the form of white crystals.

후처리

  1. temperaturewas cooled in an ice bath
  2. washwashed with dichloromethane (5 ml×3) and diethyl ether (5 ml×1)
  3. concentrationThe aqueous layer was concentrated under a reduced pressure
  4. customthe resulting residue was purified by its recrystallization from methanol

출처 및 근거

ORD 기록
ord-94292d966f7749279370642b78e9310f
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06656952B2

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