2-Aminothiazole → Cyclohexyl-[6-(2,5-dimethylphenyl)-imidazo[2,1-b]thiazol-5-yl]-amine

HRID 431230

반응식

HRID 431230 반응식
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[CH:7]1([N+:13]#[C-:14])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1.[CH3:15][C:16]1[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][C:17]=1[CH:18]=O>Cl(O)(=O)(=O)=O>[CH:7]1([NH:13][C:14]2[N:6]3[C:2]([S:3][CH:4]=[CH:5]3)=[N:1][C:18]=2[C:17]2[CH:20]=[C:21]([CH3:24])[CH:22]=[CH:23][C:16]=2[CH3:15])[CH2:12][CH2:11][CH2:10][CH2:9][CH2:8]1

참가 물질

5

반응물 3

HCID 21552-AminothiazoleHCID 220152,5-DimethylbenzaldehydeHCID 79129Cyclohexyl isocyanide

생성물 1

HCID 22335571Cyclohexyl-[6-(2,5-dimethylphenyl)-imidazo[2,1-b]thiazol-5-yl]-amine

시약·촉매·용매 1

HCID 24247Perchloric Acid용매

실험 절차

Compound 51 was prepared in accordance with the general synthesis instructions from 1.0 ml (0.1 mmol) 2-amino thiazole solution (0.1 M, MC), 0.575 ml (0.115 mmol) cyclohexylisonitrile solution (0.2 M, MC), 0.500 ml (0.15 mmol) 2,5-dimethylbenzaldehyde solution (0.3 M, MC) and 10 μl perchloric acid (w=20%) in a substance library.

출처 및 근거

ORD 기록
ord-fec350a9ff16484ea6572d95db4d29ec
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06657064B2

연결된 노트

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