Ethyl 3-oxocyclohexanecarboxylate → HCID 178517489, 화합물

HRID 431590

반응식

HRID 431590 반응식
O=[C:2]1[CH2:7][CH:6]([C:8]([O:10]CC)=O)[CH2:5][CH2:4][CH2:3]1.Cl.[Cl:14][C:15]1[CH:23]=[CH:22][C:18]([C:19]([NH2:21])=[NH:20])=[CH:17][CH:16]=1.CC([O-])(C)C.[K+]>CO>[Cl:14][C:15]1[CH:23]=[CH:22][C:18]([C:19]2[N:21]=[C:8]([OH:10])[C:6]3[CH2:7][CH2:2][CH2:3][CH2:4][C:5]=3[N:20]=2)=[CH:17][CH:16]=1

참가 물질

5

반응물 3

HCID 118096Ethyl 3-oxocyclohexanecarboxylateHCID 2034364-Chlorobenzene-1-carboximidamide hydrochlorideHCID 23665647Potassium tert-butoxide

생성물 1

HCID 178517489HCID 178517489, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

7.5 g of ethyl 2-oxocyclohexane-4-carboxylate and 9.6 g of 4-chlorobenzamidine hydrochloride were introduced into 50 ml of methanol. 5.6 g of potassium tert-butylate were added with stirring. The reaction mixture was stirred under reflux for 4 hours and then poured onto ice water. The crystalline product was filtered off with suction, washed with water and recrystallized from dimethylformamide. Yield: 8.8 g; m.p.: >300° C.

후처리

  1. stirringThe reaction mixture was stirred
  2. temperatureunder reflux for 4 hours
  3. additionpoured onto ice water
  4. filtrationThe crystalline product was filtered off with suction
  5. washwashed with water
  6. customrecrystallized from dimethylformamide

출처 및 근거

ORD 기록
ord-9f7b8dc8f11544988ea9ecdbbc059878
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06660746B1

연결된 노트

불러오는 중…