Hydrochloric Acid → Methyl 3-bromo-5-iodobenzoate
반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([I:11])[CH:10]=1)[C:5]([OH:7])=[O:6].Cl.[CH3:13]O>C(OCC)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([I:11])[CH:10]=1)[C:5]([O:7][CH3:13])=[O:6]참가 물질
5
반응 조건
- 온도
- 40 °C
실험 절차
A mixture of 3-bromo-5-iodobenzoic acid (9.0 g) in methanol (40 mL) was treated with 1M HCl in diethyl ether (27.5 mL). The reaction was heated overnight at 40° C. The solvent was then removed in vacuo, and the residue dissolved in ethyl acetate. The organic solution was washed with saturated sodium bicarbonate, dried over anhydrous sodium sulfate, filtered and concentrated to afford 8.8 g (94%) of methyl 3-bromo-5-iodobenzoate.
후처리
- customThe solvent was then removed in vacuo
- dissolutionthe residue dissolved in ethyl acetate
- washThe organic solution was washed with saturated sodium bicarbonate
- dry with materialdried over anhydrous sodium sulfate
- filtrationfiltered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-94a49d8695bb478ca21b31926b752853
- 출처 데이터셋
- uspto-grants-2003_12
- 특허 번호
- US06660753B2
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