Hydrochloric Acid → Methyl 3-bromo-5-iodobenzoate

HRID 431856

반응식

HRID 431856 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([I:11])[CH:10]=1)[C:5]([OH:7])=[O:6].Cl.[CH3:13]O>C(OCC)C>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([I:11])[CH:10]=1)[C:5]([O:7][CH3:13])=[O:6]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 51825203-Bromo-5-iodobenzoic acid

생성물 1

HCID 21942573Methyl 3-bromo-5-iodobenzoate수율 94%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
40 °C

실험 절차

A mixture of 3-bromo-5-iodobenzoic acid (9.0 g) in methanol (40 mL) was treated with 1M HCl in diethyl ether (27.5 mL). The reaction was heated overnight at 40° C. The solvent was then removed in vacuo, and the residue dissolved in ethyl acetate. The organic solution was washed with saturated sodium bicarbonate, dried over anhydrous sodium sulfate, filtered and concentrated to afford 8.8 g (94%) of methyl 3-bromo-5-iodobenzoate.

후처리

  1. customThe solvent was then removed in vacuo
  2. dissolutionthe residue dissolved in ethyl acetate
  3. washThe organic solution was washed with saturated sodium bicarbonate
  4. dry with materialdried over anhydrous sodium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-94a49d8695bb478ca21b31926b752853
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06660753B2

연결된 노트

불러오는 중…