Hydrochloric Acid → HCID 178420123, 화합물
반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[N:8]=[CH:9][N:10](C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)[CH:11]=1.Cl>O1CCCC1>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[N:8]=[CH:9][NH:10][CH:11]=1참가 물질
4
실험 절차
A solution of the crude 4-(2-pyridyl)-1-trityl-1H-imidazole (0.69g) in tetrahydrofuran (14 mL) was treated with 2 N hydrochloric acid (7.2 mL) and heated at reflux for 45 minutes. After cooling the reaction mixture was concentrated in vacuo and the residue was dissolved in dichloromethane (20 mL). The organic solution was successively washed with aqueous 1N sodium hydroxide (10 mL), water (20 mL) and brine (20 mL). The organic solution was then dried over anhydrous sodium sulfate, filtered, and concentrated in-vacuo to afford 0.12 g of crude 4-(2-pyridyl)imidazole, as a sticky white solid.
후처리
- temperatureheated
- temperatureat reflux for 45 minutes
- temperatureAfter cooling the reaction mixture
- concentrationwas concentrated in vacuo
- dissolutionthe residue was dissolved in dichloromethane (20 mL)
- washThe organic solution was successively washed with aqueous 1N sodium hydroxide (10 mL), water (20 mL) and brine (20 mL)
- dry with materialThe organic solution was then dried over anhydrous sodium sulfate
- filtrationfiltered
- concentrationconcentrated in-vacuo
출처 및 근거
- ORD 기록
- ord-53d968e1a3174d4f8f50d9e6161031f7
- 출처 데이터셋
- uspto-grants-2003_12
- 특허 번호
- US06660753B2
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