3-(4-Benzyloxyphenyl)-(S)-2-ethoxypropanoic acid ethyl ester → Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate

HRID 432078

반응식

HRID 432078 반응식
[CH2:1]([O:3][C:4](=[O:24])[C@@H:5]([O:21][CH2:22][CH3:23])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13]CC2C=CC=CC=2)=[CH:9][CH:8]=1)[CH3:2]>C(OCC)(=O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:24])[C@@H:5]([O:21][CH2:22][CH3:23])[CH2:6][C:7]1[CH:8]=[CH:9][C:10]([OH:13])=[CH:11][CH:12]=1)[CH3:2]

참가 물질

4

반응물 1

HCID 110995143-(4-Benzyloxyphenyl)-(S)-2-ethoxypropanoic acid ethyl ester

생성물 1

HCID 9816147Ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate수율 76%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

3-(4-Benzyloxyphenyl)-(S)-2-ethoxypropanoic acid ethyl ester was hydrogenated at atmospheric pressure for 2 hours in ethyl acetate using Pd/C as catalyst. Purification by chromatography on silica gel using toluen:ethyl acetate as eluant gave 3.83 g (yield in 3 steps 76%) of (S)-2-ethoxy-3-(4-hydroxyphenyl)propanoic acid ethyl ester.

후처리

  1. customPurification by chromatography on silica gel

출처 및 근거

ORD 기록
ord-ca88f86003e6446093eab14191cfa5ce
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06660879B2

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