Sodium Hydroxide → 4-Bromo-2-methoxybenzoic acid

HRID 432255

반응식

HRID 432255 반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#N)=[C:4]([O:10][CH3:11])[CH:3]=1.[OH-:12].[Na+].[O:14]1CCOCC1>>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]([OH:14])=[O:12])=[C:4]([O:10][CH3:11])[CH:3]=1

참가 물질

4

반응물 3

HCID 14798Sodium HydroxideHCID 312751,4-DioxaneHCID 223467024-Bromo-2-methoxybenzonitrile

생성물 1

HCID 134507554-Bromo-2-methoxybenzoic acid수율 37%

반응 조건

온도
100 °C

실험 절차

4-Bromo-2-methoxybenzonitrile (7.35 g, 35 mmol) was dissolved in dioxane (400 mL). Sodium hydroxide (2.0 N, 200 mL) was added and the suspension was heated at 100° C. for 16 hours. Organic solvent was removed under reduced pressure and the aqueous mixture was filtered and washed with water. The filtrate was neutralized with hydrochloric acid (5.0N) to pH 1. The solid was collected by filtration to give 4-bromo-2-methoxybenzoic acid (3 g, 37%). 1H NMR (DMSO-d6) δ 3.84 (s, 3H), 7.21 (d, J=8.25 Hz, 1H), 7.33 (s, 1H), 7.58 (d, J=8.23 Hz, 1H).

후처리

  1. customOrganic solvent was removed under reduced pressure
  2. filtrationthe aqueous mixture was filtered
  3. washwashed with water
  4. filtrationThe solid was collected by filtration

출처 및 근거

ORD 기록
ord-215c4d2fa9144088aa012f1c455182dd
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06660744B1

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