2,2-Dimethyl-3-phenylpropanoic acid → 2,2-Dimethyl-3-phenylpropanoyl chloride

HRID 432398

반응식

HRID 432398 반응식
[CH3:1][C:2]([CH3:13])([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3](O)=[O:4].C(Cl)(=O)C([Cl:17])=O>C(Cl)(Cl)Cl.CN(C)C=O>[CH3:1][C:2]([CH3:13])([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:3]([Cl:17])=[O:4]

참가 물질

5

반응물 2

HCID 218802,2-Dimethyl-3-phenylpropanoic acidHCID 65578Oxalyl chloride

생성물 1

HCID 133072292,2-Dimethyl-3-phenylpropanoyl chloride

시약·촉매·용매 2

HCID 6228Dimethylformamide촉매HCID 6212Chloroform용매

반응 조건

온도
0 °C

실험 절차

A solution of 2,2-dimethyl-3-phenylpropanoic acid (0.856 g, 4.8 mmol) in chloroform (6 mL) at 0° C. was treated with oxalyl chloride (3.05 g, 24 mmol) and 1 drop of dimethylformamide. The reaction solution was stirred for 1 h at 0° C. The ice bath was removed and the reaction mixture stirred at room temperature over night. The solvent was removed under reduced pressure and dried under high vacuum to afford a quantitative amount of 2,2-dimethyl-3-phenylpropanoyl chloride. The oil was directly used in the following reaction.

후처리

  1. customThe ice bath was removed
  2. stirringthe reaction mixture stirred at room temperature over night
  3. customThe solvent was removed under reduced pressure
  4. customdried under high vacuum

출처 및 근거

ORD 기록
ord-adbedfaa1bb149a6a18b2c46b931bf2b
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06660744B1

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