Ammonia → 2,6-Dichlorobenzenesulfonamide
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[S:9](Cl)(=[O:11])=[O:10].[NH3:13].Cl>N1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[S:9]([NH2:13])(=[O:11])=[O:10]참가 물질
5
실험 절차
A solution of 2,6-dichlorobenzenesulfonyl chloride (10.50 g, 42.77 mmol) in 100 mL of pyridine was added into 100 mL of pyridine dropwise while anhydrous ammonia gas was passing through the solution simultaneously for 4 hours at 0° C. The mixture was acidified to pH>1 with 6N aq. HCl, then extracted with ethyl acetate. The combined organic layer was then dried (Na2SO4) and concentrated to give the desired product (8.69 g, 90%). EI-MS (m/z)225.0, 227.1 (M).
후처리
- extractionextracted with ethyl acetate
- dry with materialThe combined organic layer was then dried (Na2SO4)
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-83e29e5ccda24022b928c611277eb315
- 출처 데이터셋
- uspto-grants-2003_12
- 특허 번호
- US06664259B2
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