1-Butanol → n-Butyl 1-benzoyl-3-piperidinecarboxylate

HRID 432799

반응식

HRID 432799 반응식
S1[CH:5]=[CH:4][C:3](C(N2CCCC(C(OCC)=O)C2)=O)=[CH:2]1.[C:19]([N:27]1[CH2:32][CH2:31][CH2:30][CH:29]([C:33]([OH:35])=[O:34])[CH2:28]1)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C(O)CCC>>[C:19]([N:27]1[CH2:32][CH2:31][CH2:30][CH:29]([C:33]([O:35][CH2:2][CH2:3][CH2:4][CH3:5])=[O:34])[CH2:28]1)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

참가 물질

4

반응물 3

HCID 2631-ButanolHCID 31364741-Benzoylpiperidine-3-carboxylic acidHCID 12114708Ethyl 1-(3-thiophenecarbonyl)-3-piperidinecarboxylate

생성물 1

HCID 53869174n-Butyl 1-benzoyl-3-piperidinecarboxylate

실험 절차

The reaction was run in the same manner as ethyl 1-(3-thiophenecarbonyl)-3-piperidinecarboxylate, starting with 1-benzoyl-3-piperidine carboxylic acid (500 mg; 2.1 mmol) and commercially available n-butanol (500 μl; 5.5 mmol). The crude product was distilled at 225° C./0.1 torr, giving n-butyl 1-benzoyl-3-piperidinecarboxylate (258.2 mg) as a light yellow oil. MS m/z (positive ion) 312 (M+Na+; 75), 290 (NH+; 100).

후처리

  1. distillationThe crude product was distilled at 225° C./0.1 torr

출처 및 근거

ORD 기록
ord-0217d07fab2f45c7a9c830dcd14a8100
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06664271B1

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