Water → Butyl 4-nitrophenyl carbonate

HRID 43280

반응식

HRID 43280 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)([O-:3])=[O:2].C(N([CH2:16][CH3:17])CC)C.[C:18]([O:21][CH2:22][CH3:23])(=[O:20])C.O>O1CCCC1.ClC(OCCCC)=O>[C:18](=[O:20])([O:10][C:7]1[CH:8]=[CH:9][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1)[O:21][CH2:22][CH2:23][CH2:16][CH3:17]

참가 물질

7

반응물 4

HCID 962WaterHCID 9804-NitrophenolHCID 8471TriethylamineHCID 8857Ethyl Acetate

생성물 1

HCID 12867351Butyl 4-nitrophenyl carbonate

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 61140Butyl chloroformate용매

실험 절차

Into a solution of 3.00 g of 4-nitrophenol and 3.31 mL of triethylamine in 30 mL of tetrahydrofuran, 2.75 mL of butyl chloroformate was dropped under cooling on ice. To the reaction mixture, after stirred at the same temperature for 10 min, ethyl acetate and water were added. The organic layer was separated, washed with a saturated sodium chloride aqueous solution, and dried over anhydrous magnesium sulfate. After removing the solvent by evaporation under reduced pressure, 4.60 g of butyl 4-nitrophenyl carbonate was obtained as a light yellow oily matter.

후처리

  1. temperatureunder cooling on ice
  2. customThe organic layer was separated
  3. washwashed with a saturated sodium chloride aqueous solution
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customAfter removing the solvent
  6. customby evaporation under reduced pressure

출처 및 근거

ORD 기록
ord-c9a5f1352fb34dfb8ee869cf977078d0
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536343B2

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