2-Nitropropane → 4-Methyl-4-nitrovaleronitrile

HRID 432983노트

반응식

HRID 432983 반응식
[C:1](#[N:4])[CH:2]=[CH2:3].[N+:5]([CH:8]([CH3:10])[CH3:9])([O-:7])=[O:6].[OH-].[Na+]>[Cl-].C([N+](C)(C)C)CCCCCCCCCCCCCCC>[CH3:9][C:8]([N+:5]([O-:7])=[O:6])([CH3:10])[CH2:3][CH2:2][C:1]#[N:4]

참가 물질

5

반응물 3

HCID 3982-NitropropaneHCID 7855AcrylonitrileHCID 14798Sodium Hydroxide

생성물 1

HCID 38791404-Methyl-4-nitrovaleronitrile

시약·촉매·용매 1

HCID 8154Hexadecyltrimethylammonium chloride촉매

실험 절차

(vii-1) Acrylonitrile and 2-nitropropane are reacted in the presence of hexadecyltrimethyl ammonium chloride in an aqueous alkali solvent such as aqueous sodium hydroxide solution and the like. Then, the reaction mixture is extracted to give 4-methyl-4-nitrovaleronitrile (European Journal of organic Chemistry (1998), (2), 355-357). The obtained 4-methyl-4-nitrovaleronitrile can be isolated and/or purified by a conventional method, such as crystallization, chromatography and the like, but generally, can be used in the next step without isolation and/or purification.

후처리

  1. extractionThen, the reaction mixture is extracted

출처 및 근거

ORD 기록
ord-756f7ca001c64a679544616e96739e67
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06664412B2

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