Sodium Hydroxide → 5-(4-Methyl-4-nitropentyl)hydantoin

HRID 433005노트

반응식

HRID 433005 반응식
[CH3:1][C:2]([N+:14]([O-:16])=[O:15])([CH3:13])[CH2:3][CH2:4][CH:5]=[C:6]1[NH:10][C:9](=[O:11])[NH:8][C:7]1=[O:12].[OH-].[Na+].[H][H]>[C].[Pd].CO>[CH3:13][C:2]([N+:14]([O-:16])=[O:15])([CH3:1])[CH2:3][CH2:4][CH2:5][CH:6]1[NH:10][C:9](=[O:11])[NH:8][C:7]1=[O:12]

참가 물질

6

반응물 3

HCID 14798Sodium HydroxideHCID 695837495-(4-Methyl-4-nitropentylidene)hydantoinHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 99427025-(4-Methyl-4-nitropentyl)hydantoin수율 72.9%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매2회HCID 887Methanol용매

실험 절차

Methanol (200 ml) was added to 5-(4-methyl-4-nitropentylidene)hydantoin (25.85 g, 114 mmol) and 27% aqueous sodium hydroxide solution was added to adjust the pH to 10 for dissolution. Palladium-carbon (1.1 g) and hydrogen were added for reduction. After the reaction, palladium-carbon was filtered off and methanol was evaporated by concentration under reduced pressure. Water (50 ml) was added and the pH was adjusted to 2 with concentrated hydrochloric acid. The precipitated crystals were separated and dried to give 5-(4-methyl-4-nitropentyl)hydantoin (19.02 g, 83 mmol, yield 72.9%).

후처리

  1. additionwas added
  2. dissolutionfor dissolution
  3. filtrationwas filtered off
  4. custommethanol was evaporated by concentration under reduced pressure
  5. additionWater (50 ml) was added
  6. customThe precipitated crystals were separated
  7. customdried

출처 및 근거

ORD 기록
ord-7cc74fbf3b544f4984ad8eeef9695e61
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06664412B2

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