Pyridine → Isobutyl 2-bromopropionate

HRID 433457

반응식

HRID 433457 반응식
[CH2:1]([OH:5])[CH:2]([CH3:4])[CH3:3].N1C=CC=CC=1.[Br:12][CH:13]([CH3:17])[C:14](Br)=[O:15]>C(OCC)C>[Br:12][CH:13]([CH3:17])[C:14]([O:5][CH2:1][CH:2]([CH3:4])[CH3:3])=[O:15]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 6560IsobutanolHCID 79047Propanoyl bromide, 2-bromo-

생성물 1

HCID 522337Isobutyl 2-bromopropionate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

To a mixture of iso-butanol and 1.0 equivalent of pyridine in dry diethyl ether was added dropwise 1.3 equivalents of 2-bromopropionyl bromide at 0° C. After stirring at room temperature for 16 hours, the reaction was diluted with diethyl ether, washed with 1N HCl, water, aqueous NaHCO3, brine and dried over magnesium sulfate or sodium sulfate. Removal of the solvents at reduced pressure gave the title compound as a clear oil.

후처리

  1. washwashed with 1N HCl, water, aqueous NaHCO3, brine
  2. dry with materialdried over magnesium sulfate or sodium sulfate
  3. customRemoval of the solvents at reduced pressure

출처 및 근거

ORD 기록
ord-6a6f95ceb1de49479055510426e79809
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06667305B1

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