3-Fluoroaniline → tert-Butyl 4-(3-fluoroanilino)piperidine-1-carboxylate

HRID 43359

반응식

HRID 43359 반응식
C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].O=[C:16]1[CH2:21][CH2:20][N:19]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:18][CH2:17]1.[F:29][C:30]1[CH:31]=[C:32]([CH:34]=[CH:35][CH:36]=1)[NH2:33]>C(OC(C)C)(=O)C>[F:29][C:30]1[CH:31]=[C:32]([NH:33][CH:16]2[CH2:21][CH2:20][N:19]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[CH2:18][CH2:17]2)[CH:34]=[CH:35][CH:36]=1

참가 물질

5

반응물 3

HCID 97423-FluoroanilineHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylateHCID 5049666Sodium triacetoxyborohydride

생성물 1

HCID 23137591tert-Butyl 4-(3-fluoroanilino)piperidine-1-carboxylate

시약·촉매·용매 1

HCID 7915Isopropyl Acetate용매

실험 절차

Sodium triacetoxyborohydride (NaBH(OAc)3 74 g, 0.35 mol) was added to a stirred solution of 1,1-Dimethylethyl 4-oxo-1-piperidinecarboxylate (50 g, 0.25 mol) and 3-Fluoroaniline (24 ml, 0.25 mol) in isopropyl acetate (1-PrOAc, 500 ml) and the slurry stirred overnight.

출처 및 근거

ORD 기록
ord-37cc2d7a1d7c499ab3bcccd0f2ba04eb
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536182B2

연결된 노트

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