Acetic Acid → 1-(3-Bromophenyl)-1H-imidazole-4-carboxylic acid

HRID 433617노트

반응식

HRID 433617 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[CH:9](OCC)(OCC)OCC.[N+:19]([CH2:22]C(OCC)=O)([O-])=O.[C:28]([OH:31])(=[O:30])[CH3:29]>[Fe]>[Br:1][C:2]1[CH:3]=[C:4]([N:5]2[CH:9]=[C:29]([C:28]([OH:31])=[O:30])[N:19]=[CH:22]2)[CH:6]=[CH:7][CH:8]=1

참가 물질

6

반응물 4

HCID 176Acetic Acid2회HCID 115623-BromoanilineHCID 31214Ethyl orthoformate2회HCID 69379Ethyl nitroacetate

생성물 1

HCID 234449541-(3-Bromophenyl)-1H-imidazole-4-carboxylic acid

시약·촉매·용매 1

HCID 23925Iron촉매

실험 절차

Following the general method described in example 234, 3-bromoaniline was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid and subsequent alkaline hydrolysis. The title compound was obtained as a light brown crystalline solid. Mp. 205-207° C. (H2O/dioxane), MS: m/e=267 (M-H−).

출처 및 근거

ORD 기록
ord-ddcabea0d83949489e4d63c746a87c83
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06667335B2

반응 노트

불러오는 중…