Acetic Acid → 1-(3-Difluoromethyl-4-fluoro-phenyl)-1H-imidazole-4-carboxylic Acid
반응식
[F:1][CH:2]([F:11])[C:3]1[CH:4]=[C:5]([CH:7]=[CH:8][C:9]=1[F:10])[NH2:6].[CH:12](OCC)(OCC)OCC.[N+:22]([CH2:25]C(OCC)=O)([O-])=O.[C:31]([OH:34])(=[O:33])[CH3:32]>[Fe]>[F:11][CH:2]([F:1])[C:3]1[CH:4]=[C:5]([N:6]2[CH:12]=[C:32]([C:31]([OH:34])=[O:33])[N:22]=[CH:25]2)[CH:7]=[CH:8][C:9]=1[F:10]참가 물질
6
실험 절차
Following the general method described in example 234, 3-difluoromethyl-4-fluoroaniline was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid and subsequent alkaline hydrolysis. The title compound was obtained as a light brown crystalline solid. Mp. >247° C. dec. (H2O/dioxane), MS: m/e=255 (M-H−).
출처 및 근거
- ORD 기록
- ord-eefacf6657dd4aaa964d55ca05586d76
- 출처 데이터셋
- uspto-grants-2003_12
- 특허 번호
- US06667335B2
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