Acetic Acid → HCID 23445189, 화합물

HRID 433628노트

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HRID 433628 반응식
[F:1][CH:2]([F:11])[O:3][C:4]1[CH:5]=[C:6]([CH:8]=[CH:9][CH:10]=1)[NH2:7].[CH:12](OCC)(OCC)OCC.[N+:22]([CH2:25]C(OCC)=O)([O-])=O.[C:31]([OH:34])(=[O:33])[CH3:32]>[Fe]>[F:1][CH:2]([F:11])[O:3][C:4]1[CH:5]=[C:6]([N:7]2[CH:12]=[C:32]([C:31]([OH:34])=[O:33])[N:22]=[CH:25]2)[CH:8]=[CH:9][CH:10]=1

참가 물질

6

반응물 4

HCID 176Acetic Acid2회HCID 31214Ethyl orthoformate2회HCID 69379Ethyl nitroacetateHCID 27741103-(Difluoromethoxy)aniline

생성물 1

HCID 23445189HCID 23445189, 화합물

시약·촉매·용매 1

HCID 23925Iron촉매

실험 절차

Following the general method described in example 234, 3-(difluoromethoxy)aniline was reacted with triethyl orthoformate, ethyl nitroacetate and acetic acid followed by treatment with triethyl orthoformate, iron and acetic acid and subsequent alkaline hydrolysis. The title compound was obtained as a light brown crystalline solid. Mp. 190-191° C. (H2O/dioxane), MS: m/e=253 (M-H−).

출처 및 근거

ORD 기록
ord-1c7438ed1d6a4ebcb9775e295e61a40f
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06667335B2

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