Boron, trifluoro(methanol)-, (T-4)- → HCID 86584267, 화합물

HRID 433727

반응식

HRID 433727 반응식
CO.B(F)(F)F.C([NH:10][C:11]1[C:12]([F:32])=[CH:13][C:14]([Cl:31])=[C:15]([CH:30]=1)[O:16][C:17]1[CH:29]=[CH:28][CH:27]=[CH:26][C:18]=1[O:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22])(=O)C>>[NH2:10][C:11]1[C:12]([F:32])=[CH:13][C:14]([Cl:31])=[C:15]([CH:30]=1)[O:16][C:17]1[CH:29]=[CH:28][CH:27]=[CH:26][C:18]=1[O:19][CH2:20][C:21]([O:23][CH2:24][CH3:25])=[O:22]

참가 물질

3

반응물 2

HCID 11062313Boron, trifluoro(methanol)-, (T-4)-HCID 86584266HCID 86584266, 화합물

생성물 1

HCID 86584267HCID 86584267, 화합물

실험 절차

Into a boron trifluoride methanol complex methanol solution is added ethyl [2-(5-acetylamino-2-chloro-4-fluorophenoxy)phenoxy]acetate, and the mixture is heated while stirring. Thereafter, the reaction solution is concentrated, the residue is dissolved in ethyl acetate, and washed with saturated aqueous sodium bicarbonate, dried over magnesium sulfate, and concentrated to obtain ethyl [2-(5-amino-2-chloro-4-fluorophenoxy)phenoxy]acetate [Intermediate compound A3-23].

후처리

  1. temperaturethe mixture is heated
  2. concentrationThereafter, the reaction solution is concentrated
  3. dissolutionthe residue is dissolved in ethyl acetate
  4. washwashed with saturated aqueous sodium bicarbonate
  5. dry with materialdried over magnesium sulfate
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-33db2df52e6946c8b20f6fd6038ad6ce
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06667413B2

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