Methanol → 2-(1-Pyrrolidinyl)-4-(hydroxymethyl)thiazole

HRID 433760노트

반응식

HRID 433760 반응식
[N:1]1([C:6]2[S:7][CH:8]=[C:9]([C:11](OCC)=[O:12])[N:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.CO>C(Cl)(Cl)Cl>[N:1]1([C:6]2[S:7][CH:8]=[C:9]([CH2:11][OH:12])[N:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 887MethanolHCID 13339674Ethyl 2-(pyrrolidin-1-yl)thiazole-4-carboxylate

생성물 1

HCID 187591502-(1-Pyrrolidinyl)-4-(hydroxymethyl)thiazole수율 4%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Using the procedure of Example 11C but replacing ethyl 2-(4-morpholinyl)thiazole-4-carboxylate with ethyl 2-(1-pyrrolidinyl)thiazole-4-carboxylate provided, after silica gel chromatography using 2-4% methanol in chloroform, the desired compound (Rf 0.26, 4% methanol in chloroform) in 53% yield. 1H NMR (CDCl3) δ 2.04 (m, 4H), 2.75 (br, 1H), 3.45 (m, 4H), 4.56 (s, 2H), 6.32 (s, 1H). Mass spectrum: (M+H)+185.

후처리

  1. customprovided

출처 및 근거

ORD 기록
ord-a7a3e489b083415cae1684aabef8eed4
출처 데이터셋
uspto-grants-2003_12
특허 번호
US06667404B2

반응 노트

불러오는 중…