Phenacyl bromide → 6,6-Dimethyl-8-Keto-2-Phenyl-5,6,7,8-Tetrahydroimidazo[2,1-b]Benzothiazole

HRID 434314노트

반응식

HRID 434314 반응식
[NH2:1][C:2]1[S:3][C:4]2[C:10](=[O:11])[CH2:9][C:8]([CH3:13])([CH3:12])[CH2:7][C:5]=2[N:6]=1.Br[CH2:15][C:16]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=O>C(Cl)(Cl)Cl>[CH3:12][C:8]1([CH3:13])[CH2:7][C:5]2[N:6]3[CH:15]=[C:16]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[N:1]=[C:2]3[S:3][C:4]=2[C:10](=[O:11])[CH2:9]1

참가 물질

4

반응물 2

HCID 6259Phenacyl bromideHCID 5878742-Amino-5,5-dimethyl-5,6-dihydro-4H-benzothiazol-7-one

생성물 1

HCID 9143496,6-Dimethyl-8-Keto-2-Phenyl-5,6,7,8-Tetrahydroimidazo[2,1-b]Benzothiazole

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A 0.08 m. quantity each of 2-amino-5,5-dimethyl-7-keto-4,5,6,7-tetrahydrobenzothiazole and α-bromoacetophenone are mixed in 150 ml. of chloroform and heated at reflux for 4 hours. The slurry is filtered hot and the insoluble intermediate product is suspended in 600 ml. of water containing 25 g. of sodium acetate. This suspension is heated slowly to boil over 21/2 hours, then allowed to cool. The product is filtered off, washed well with water and dried yielding 12.5 g. of product melting at 175°-178° C. and having the structure: ##STR15##

후처리

  1. temperatureat reflux for 4 hours
  2. filtrationThe slurry is filtered hot
  3. temperatureThis suspension is heated slowly
  4. custom2 hours
  5. temperatureto cool
  6. filtrationThe product is filtered off
  7. washwashed well with water
  8. customdried
  9. customyielding 12.5 g

출처 및 근거

ORD 기록
ord-d401c9203f6d4ba5af27d85deeb646a4
출처 데이터셋
uspto-grants-1983_08
특허 번호
US04396547

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