Hydroxide → 2-Methyl-4-morpholino-5-fluoroindole

HRID 434678

반응식

HRID 434678 반응식
[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[C:8]([N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)[C:7]([F:17])=[CH:6][C:5]=2Br.[OH-].[H][H]>C(O)C.[C].[Pd]>[CH3:1][C:2]1[NH:3][C:4]2[C:9]([CH:10]=1)=[C:8]([N:11]1[CH2:12][CH2:13][O:14][CH2:15][CH2:16]1)[C:7]([F:17])=[CH:6][CH:5]=2

참가 물질

6

반응물 3

HCID 961HydroxideHCID 202589932-Methyl-4-morpholino-5-fluoro-7-bromoindoleHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 202589922-Methyl-4-morpholino-5-fluoroindole수율 65.7%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 702Ethanol용매

실험 절차

To a solution of 24 g of 2-methyl-4-morpholino-5-fluoro-7-bromoindole in 200 ml of ethanol was added 1 g of palladium-carbon and then 15 ml of a 20% aqueous sodiium hydroxide solution. This mixture was subjected to catalytic reduction at room temperature and at atmospheric pressure. The reaction was stopped when a theoretical amount (about 1.7 l) of hydrogen was absorbed, and the catalyst was removed by filtration followed by concentration. The residue was purified through silica gel column chromatography (Wako gel C-200; eluent:chloroform:n-hexane=5:1) to give 11.8 g of 2-methyl-4-morpholino-5-fluoroindole.

후처리

  1. customwas subjected to catalytic reduction at room temperature and at atmospheric pressure
  2. customwas absorbed
  3. customthe catalyst was removed by filtration
  4. concentrationfollowed by concentration
  5. customThe residue was purified through silica gel column chromatography (Wako gel C-200; eluent:chloroform:n-hexane=5:1)

출처 및 근거

ORD 기록
ord-f82e5e9786934fb2a560732e42ba15b4
출처 데이터셋
uspto-grants-1983_08
특허 번호
US04399134

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