2-(dimethoxymethyl)-5-ethyl-4-(trifluoromethyl)-1H-imidazole → 5-Ethyl-4-(trifluoromethyl)-1H-imidazole-2-carbaldehyde

HRID 43474

반응식

HRID 43474 반응식
C[O:2][CH:3](OC)[C:4]1[NH:5][C:6]([CH2:13][CH3:14])=[C:7]([C:9]([F:12])([F:11])[F:10])[N:8]=1>S(=O)(=O)(O)O>[CH2:13]([C:6]1[NH:5][C:4]([CH:3]=[O:2])=[N:8][C:7]=1[C:9]([F:11])([F:12])[F:10])[CH3:14]

참가 물질

3

반응물 1

HCID 684060432-(dimethoxymethyl)-5-ethyl-4-(trifluoromethyl)-1H-imidazole

생성물 1

HCID 866484875-Ethyl-4-(trifluoromethyl)-1H-imidazole-2-carbaldehyde수율 29.1%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

The same operation as in Example (33b) was performed using 2-(dimethoxymethyl)-5-ethyl-4-(trifluoromethyl)-1H-imidazole obtained in Example (39c) (about 4.09 mmol) and 2 N sulfuric acid (30 mL), to obtain 228.3 mg of the title compound as a white solid (29%).

출처 및 근거

ORD 기록
ord-c2732bdc31d840f1a6f62f8d8476e4c5
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536197B2

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