Water → HCID 20492177, 화합물

HRID 434779노트

반응식

HRID 434779 반응식
P(Cl)(Cl)(Cl)=O.[O:6]1[CH:10]=[CH:9][CH:8]=[C:7]1[CH2:11][S:12][CH2:13][CH2:14][N:15]1[C:23](=[O:24])[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[C:16]1=[O:25].O.[CH:27]([OH:30])(C)C>CN(C)C=O>[CH:27]([C:10]1[O:6][C:7]([CH2:11][S:12][CH2:13][CH2:14][N:15]2[C:23](=[O:24])[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[C:16]2=[O:25])=[CH:8][CH:9]=1)=[O:30]

참가 물질

6

반응물 4

HCID 962WaterHCID 3776IsopropanolHCID 24813Phosphorus oxychlorideHCID 132542762-(2-{[(Furan-2-yl)methyl]sulfanyl}ethyl)-1H-isoindole-1,3(2H)-dione

생성물 1

HCID 20492177HCID 20492177, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

실험 절차

A solution of phosphoryl chloride (21.4 g) in dry dimethylformamide (40 ml), cooled in ice, was added portionwise to a solution of N-[2-[(2-furanylmethyl)thio]ethyl]-1H-isoindole-1,3(2H)-dione (21.4 g) in dry dimethylformamide (70 ml). After 5 hours at room temperature, the solution was poured into iced water (1.7 l). Isopropyl alcohol (150 ml) was added and after 18 hours the solid which separated was filtered and crystallised from ethyl acetate-ether to give the title compound (22.3 g) m.p. 76°-77°.

후처리

  1. customseparated
  2. filtrationwas filtered
  3. customcrystallised from ethyl acetate-ether

출처 및 근거

ORD 기록
ord-1eacc8d32d3c4d44976bc24771abbedd
출처 데이터셋
uspto-grants-1983_08
특허 번호
US04399294

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