Sodium Hydroxide → 2-(2-Amino-4-thiazolyl)-2-ethoxyiminoacetic acid
반응식
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:13][O:14][CH2:15][CH3:16])[C:8]([O:10]CC)=[O:9])[N:6]=1.[OH-].[Na+]>C(O)C>[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:13][O:14][CH2:15][CH3:16])[C:8]([OH:10])=[O:9])[N:6]=1참가 물질
4
실험 절차
Ethyl 2-(2-amino-4-thiazolyl)-2-ethoxyiminoacetate (syn isomer, 5 g.) was added to a mixture of 1 N sodium hydroxide (45.9 ml.) and ethanol (30 ml.) and stirred at room temperature for 5 hours. After removing ethanol from the resultant solution under reduced pressure, the residue was dissolved in water (60 ml.) and adjusted to pH 2.0 with 10% hydrochloric acid. The solution was subjected to salting-out, and the precipitates were collected by filtration and dried to give 2-(2-amino-4-thiazolyl)-2-ethoxyiminoacetic acid (syn isomer, 2.9 g.).
후처리
- customAfter removing ethanol from the resultant solution under reduced pressure
- dissolutionthe residue was dissolved in water (60 ml.)
- filtrationthe precipitates were collected by filtration
- customdried
출처 및 근거
- ORD 기록
- ord-33bafaf13c94419e93d5f4c90aec23f4
- 출처 데이터셋
- uspto-grants-1983_08
- 특허 번호
- US04399133
반응 노트
불러오는 중…