Methanol → 2-(2-Aminothiazol-4-yl)-2-isobutoxyiminoacetic acid

HRID 434904노트

반응식

HRID 434904 반응식
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:13][O:14][CH2:15][CH:16]([CH3:18])[CH3:17])[C:8]([O:10]CC)=[O:9])[N:6]=1.[OH-].[Na+].CO>O1CCCC1>[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:13][O:14][CH2:15][CH:16]([CH3:18])[CH3:17])[C:8]([OH:10])=[O:9])[N:6]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 53811669Ethyl 2-(2-aminothiazol-4-yl)-2-iso-butoxyiminoacetate

생성물 1

HCID 539681782-(2-Aminothiazol-4-yl)-2-isobutoxyiminoacetic acid수율 91.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Ethyl 2-(2-aminothiazol-4-yl)-2-iso-butoxyiminoacetate (syn isomer, 19.6 g.), 2 N aqueous solution of sodium hydroxide (72.2 ml.), methanol (72.2 ml.) and tetrahydrofuran (72.2 ml.) were treated in a similar manner to that of Example F-(4) to give 2-(2-aminothiazol-4-yl)-2-isobutoxyiminoacetic acid (syn isomer, 16.1 g.), mp 180° C. (dec.).

출처 및 근거

ORD 기록
ord-c30581eeae564b26ad46bbf71384744d
출처 데이터셋
uspto-grants-1983_08
특허 번호
US04399133

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