Methanol → 2-(2-Aminothiazol-4-yl)-2-n-hexyloxyiminoacetic acid

HRID 434917노트

반응식

HRID 434917 반응식
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:13][O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:8]([O:10]CC)=[O:9])[N:6]=1.CO.[OH-].[Na+]>O1CCCC1>[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:13][O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH3:20])[C:8]([OH:10])=[O:9])[N:6]=1

참가 물질

5

반응물 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 53940552Ethyl 2-(2-aminothiazol-4-yl)2-n-hexyloxyiminoacetate

생성물 1

HCID 540705992-(2-Aminothiazol-4-yl)-2-n-hexyloxyiminoacetic acid수율 91%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Ethyl 2-(2-aminothiazol-4-yl)2-n-hexyloxyiminoacetate (syn isomer, 29.1 g.), methanol (97.2 ml.), 2 N aqueous solution of sodium hydroxide (97.2 ml.) and tetrahydrofuran (50 ml.) were treated in a similar manner to that of Example F-(4) to give 2-(2-aminothiazol-4-yl)-2-n-hexyloxyiminoacetic acid (syn isomer, 24.0 g.), mp. 174° C. (dec.).

출처 및 근거

ORD 기록
ord-7a0bceabaf634b0cbceb9c370de7420a
출처 데이터셋
uspto-grants-1983_08
특허 번호
US04399133

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