Methanol → 2-(2-Aminothiazol-4-yl)-2-(2-chloroethoxyimino)acetic acid
반응식
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:13][O:14][CH2:15][CH2:16][Cl:17])[C:8]([O:10]CC)=[O:9])[N:6]=1.[OH-].[Na+].CO>O1CCCC1>[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:13][O:14][CH2:15][CH2:16][Cl:17])[C:8]([OH:10])=[O:9])[N:6]=1참가 물질
5
실험 절차
Ethyl 2-(2-aminothiazol-4-yl)-2-(2-chloroethoxyimino)acetate (syn isomer, 30.5 g.), 1 N aqueous solution of sodium hydroxide (220 ml.), methanol (110 ml.) and tetrahydrofuran (140 ml.) were treated in a similar manner to that of Example F-(4) to give 2-(2-aminothiazol-4-yl)-2-(2-chloroethoxyimino)acetic acid (syn isomer, 23.4 g.), mp 201° C. (dec.).
출처 및 근거
- ORD 기록
- ord-bd7dd7fdfba646618f5a3c11419db1a7
- 출처 데이터셋
- uspto-grants-1983_08
- 특허 번호
- US04399133
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