Bromine → Methyl 4-bromo-3-oxopentanoate

HRID 43517

반응식

HRID 43517 반응식
[O:1]=[C:2]([CH2:8][CH3:9])[CH2:3][C:4]([O:6][CH3:7])=[O:5].[Br:10]Br>C(Cl)(Cl)Cl>[Br:10][CH:8]([CH3:9])[C:2](=[O:1])[CH2:3][C:4]([O:6][CH3:7])=[O:5]

참가 물질

4

반응물 2

HCID 24408BromineHCID 121699Methyl 3-oxovalerate

생성물 1

HCID 9815681Methyl 4-bromo-3-oxopentanoate

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

Methyl 3-oxopentanoate (1 g, 7.68 mmol) was dissolved in chloroform (30 mL). Bromine (0.4 mL, 7.80 mmol) was added under ice-cooling and the mixture was stirred for 40 minutes. The reaction solution was washed with saturated aqueous sodium bicarbonate solution, dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The resulting compound was used for the next reaction without purification.

후처리

  1. temperaturecooling
  2. washThe reaction solution was washed with saturated aqueous sodium bicarbonate solution
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure
  5. customThe resulting compound was used for the next reaction without purification

출처 및 근거

ORD 기록
ord-eeb1d3c862ba4424958c3286cfe142e9
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536197B2

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