Butyl iodide → 1-(5-Acetyl-3-butyl-2,4-dihydroxyphenyl)ethanone

HRID 435203

반응식

HRID 435203 반응식
[C:1]([C:4]1[CH:10]=[C:9]([C:11](=[O:13])[CH3:12])[C:7]([OH:8])=[CH:6][C:5]=1[OH:14])(=[O:3])[CH3:2].[OH-].[Na+].I[CH2:18][CH2:19][CH2:20][CH3:21]>O>[CH2:18]([C:6]1[C:7]([OH:8])=[C:9]([C:11](=[O:13])[CH3:12])[CH:10]=[C:4]([C:1](=[O:3])[CH3:2])[C:5]=1[OH:14])[CH2:19][CH2:20][CH3:21]

참가 물질

5

반응물 3

HCID 10962Butyl iodideHCID 14798Sodium HydroxideHCID 750974,6-Diacetylresorcinol

생성물 1

HCID 27751671-(5-Acetyl-3-butyl-2,4-dihydroxyphenyl)ethanone

시약·촉매·용매 1

HCID 962Water용매

실험 절차

4,6-Diacetyl resorcinol (485 g, 2.5 m) sodium hydroxide (220 g, 5 m), 1-iodobutane (285 ml, 2.5 m) and water (2 l) were heated on a steam bath for 16 hours, cooled to 20° and the yellow-white precipitate filtered and washed with water. The solid was washed with dilute hydrochloric acid, extracted into chloroform (2×1.5 l) and the chloroform solution washed with water (2 l) and brine (1 l), then dried (anhyd. Na2SO4). Filtration and removal of solvent gave an oil (420 g) which crystallised on standing.

후처리

  1. temperaturecooled to 20°
  2. filtrationthe yellow-white precipitate filtered
  3. washwashed with water
  4. washThe solid was washed with dilute hydrochloric acid
  5. extractionextracted into chloroform (2×1.5 l)
  6. washthe chloroform solution washed with water (2 l) and brine (1 l)
  7. dry with materialdried (anhyd. Na2SO4)
  8. filtrationFiltration and removal of solvent

출처 및 근거

ORD 기록
ord-e8faf5cc04d049b79b4b4ea636fbb0b6
출처 데이터셋
uspto-grants-1983_08
특허 번호
US04400542

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