Acetic Anhydride → 2-(2-Formamidothiazol-4-yl)-2-isopropoxyiminoacetic acid

HRID 435242노트

반응식

HRID 435242 반응식
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:11][O:12][CH:13]([CH3:15])[CH3:14])[C:8]([OH:10])=[O:9])[N:6]=1.[C:16](OC(=O)C)(=[O:18])C>C(O)=O>[CH:16]([NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7](=[N:11][O:12][CH:13]([CH3:15])[CH3:14])[C:8]([OH:10])=[O:9])[N:6]=1)=[O:18]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 541000552-Isopropoxyimino-2-(2-aminothiazol-4-yl)acetic acid

생성물 1

HCID 538092752-(2-Formamidothiazol-4-yl)-2-isopropoxyiminoacetic acid수율 83.5%

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

2-(2-Aminothiazol-4-yl)-2-iso-propoxyiminoacetic acid (syn isomer, 4 g.), acetic anhydride (7.6 g. ) and formic acid (3.4 g.) were treated in a similar manner to that of Example F-(5) to give 2-(2-formamidothiazol-4-yl)-2-iso-propoxyiminoacetic acid (syn isomer, 3.75 g.), mp. 168° to 169° C. (dec.).

출처 및 근거

ORD 기록
ord-404f47ebbb274bb6846ad29c703090fd
출처 데이터셋
uspto-grants-1983_08
특허 번호
US04400379

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