Dichloromethane → 1-(4-Carbomethoxy-2-methylbutanoyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid methyl ester

HRID 435461

반응식

HRID 435461 반응식
[CH3:1][O:2][C:3]([CH:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6]1)=[O:4].[C:15]([CH2:19][CH2:20][CH:21]([CH3:25])[C:22](Cl)=[O:23])([O:17][CH3:18])=[O:16].C(=O)([O-])[O-].[K+].[K+].C(Cl)Cl>O>[CH3:1][O:2][C:3]([CH:5]1[CH2:14][CH2:13][C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]1[C:22](=[O:23])[CH:21]([CH3:25])[CH2:20][CH2:19][C:15]([O:17][CH3:18])=[O:16])=[O:4]

참가 물질

6

반응물 4

HCID 6344DichloromethaneHCID 11430Potassium CarbonateHCID 2736972Methyl 1,2,3,4-tetrahydroquinoline-2-carboxylateHCID 13192898Methyl 5-chloro-4-methyl-5-oxopentanoate

생성물 1

HCID 131928991-(4-Carbomethoxy-2-methylbutanoyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid methyl ester

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The mixture of 1.0 g of 1,2,3,4-tetrahydroquinoline-2-carboxylic acid methyl ester (Ber. 61,2377), 0.87 g of 4-carbomethoxy-2-methylbutanoyl chloride, 1.44 g of powdered potassium carbonate and 20 ml of methylene chloride is stirred at room temperature overnight. It is cooled with ice, and 50 ml of water are added. The organic layer is separated, washed with N-hydrochloric acid and water, dried and evaporated, to yield the 1-(4-carbomethoxy-2-methylbutanoyl)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid methyl ester, showing NMR-peaks at 0.85, 1.25, 3.35, 3.65 and 3.75 ppm.

후처리

  1. additionare added
  2. customThe organic layer is separated
  3. washwashed with N-hydrochloric acid and water
  4. customdried
  5. customevaporated

출처 및 근거

ORD 기록
ord-624f9efadedf425586d828304aa9291a
출처 데이터셋
uspto-grants-1983_08
특허 번호
US04401818

연결된 노트

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