Sodium borohydride → HCID 12223972, 화합물

HRID 435648노트

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HRID 435648 반응식
[CH3:1][N:2]([CH3:22])[S:3]([C:6]1[CH:21]=[CH:20][C:9]2[S:10][C:11]3[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=3[C:13](=[O:15])[CH2:14][C:8]=2[CH:7]=1)(=[O:5])=[O:4].[BH4-].[Na+]>O1CCOCC1.O>[CH3:1][N:2]([CH3:22])[S:3]([C:6]1[CH:21]=[CH:20][C:9]2[S:10][C:11]3[CH:19]=[CH:18][CH:17]=[CH:16][C:12]=3[CH:13]([OH:15])[CH2:14][C:8]=2[CH:7]=1)(=[O:5])=[O:4]

참가 물질

5

반응물 2

HCID 4311764Sodium borohydrideHCID 1222396710,11-Dihydro-2-dimethylsulphamoyl-dibenzo[b,f]-thiepin-10-one

생성물 1

HCID 12223972HCID 12223972, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

반응 조건

온도
40 °C

실험 절차

14 g of 10,11-dihydro-2-dimethylsulphamoyl-dibenzo[b,f]-thiepin-10-one in 200 ml of dioxane are treated with 3.5 g of sodium borohydride in 15 ml of water and the mixture is stirred at 40° C for 4 hours. The mixture is evaporated under reduced pressure and the residue taken up in ethyl acetate and water. The organic phase is washed with water, dried and evaporated. 10,11-dihydro-2-dimethylsulphamoyl-dibenzo[b,f]-thiepin-10-ol is obtained.

후처리

  1. customThe mixture is evaporated under reduced pressure
  2. washThe organic phase is washed with water
  3. customdried
  4. customevaporated

출처 및 근거

ORD 기록
ord-631ff691337d4810aca4a648f6e125e1
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04006145

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