Water → 2-Phenylthio-5-trifluoromethyl-phenylacetonitrile

HRID 435656노트

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HRID 435656 반응식
[C-:1]#[N:2].[Na+].[C:4]1([S:10][C:11]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][C:12]=2[CH2:13]Cl)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.O>CS(C)=O>[C:4]1([S:10][C:11]2[CH:18]=[CH:17][C:16]([C:19]([F:22])([F:21])[F:20])=[CH:15][C:12]=2[CH2:13][C:1]#[N:2])[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 8929Sodium CyanideHCID 15619001HCID 15619001, 화합물

생성물 1

HCID 122239582-Phenylthio-5-trifluoromethyl-phenylacetonitrile

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매2회

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온도
40 °C

실험 절차

11.2 g of sodium cyanide in 135 ml of dimethyl sulphoxide are warmed to 40° c and treated dropwise over a period of 10 minutes with a solution of 87 g of 2-(phenylthio)-5-trifluoromethyl-benzyl chloride in 72 ml of dimethyl sulphoxide. The mixture is stirred at 40° C for 9 hours, cooled to room temperature, treated with 200 ml of water and extracted with 200 ml of ether. The aqueous phase is then extracted twice with 100 ml of ether each time. The combined organic phases are now washed twice with 200 ml of water each time, dried over sodium sulphate and evaporated under reduced pressure. There is obtained 2-(phenylthio)-5-trifluoromethyl-phenylacetonitrile as a dark-red oil.

후처리

  1. temperaturecooled to room temperature
  2. extractionextracted with 200 ml of ether
  3. extractionThe aqueous phase is then extracted twice with 100 ml of ether each time
  4. washThe combined organic phases are now washed twice with 200 ml of water each time
  5. dry with materialdried over sodium sulphate
  6. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-156bfe3bd03f49fabfdfd57cc044565e
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04006145

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