Sodium Cyanide → HCID 12232352, 화합물
반응식
[C-:1]#[N:2].[Na+].[F:4][C:5]1[CH:6]=[C:7]([C:10]([S:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:11][CH:12]=1)[CH2:8]Cl>CS(C)=O>[F:4][C:5]1[CH:6]=[C:7]([CH2:8][C:1]#[N:2])[C:10]([S:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:11][CH:12]=1참가 물질
4
실험 절차
18.6 g of sodium cyanide in 222 ml of dimethyl sulphoxide are treated at 50° C with 74 g of 3-fluoro-6-(phenylthio)-benzyl chloride in 75 ml of dimethyl sulphoxide in one portion. The resulting dark solution is stirred at 45°-50° C for 1 hour, subsequently poured on to 1500 ml of ice-water and extracted with ether. The organic phase is washed three times with 500 ml of water each time, dried over sodium sulphate and evaporated. There is obtained 3-fluoro-6-(phenylthio)-phenylacetonitrile as a reddish oil.
후처리
- extractionextracted with ether
- washThe organic phase is washed three times with 500 ml of water each time
- dry with materialdried over sodium sulphate
- customevaporated
출처 및 근거
- ORD 기록
- ord-c3ddf21f310245efb94e33ec4295c55b
- 출처 데이터셋
- uspto-grants-1977_02
- 특허 번호
- US04006144
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