2,3,5-Trimethylanisole → (4-Methoxy-2,3,6-trimethylphenyl)(5-nitro-1,3-thiazol-2-yl)methanone

HRID 435812

반응식

HRID 435812 반응식
[N+:1]([C:4]1[S:8][C:7]([C:9](Cl)=[O:10])=[N:6][CH:5]=1)([O-:3])=[O:2].[CH3:12][C:13]1[C:18]([CH3:19])=[CH:17][C:16]([CH3:20])=[CH:15][C:14]=1[O:21][CH3:22].[Cl-].[Al+3].[Cl-].[Cl-]>C(Cl)Cl>[CH3:22][O:21][C:14]1[CH:15]=[C:16]([CH3:20])[C:17]([C:9]([C:7]2[S:8][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][N:6]=2)=[O:10])=[C:18]([CH3:19])[C:13]=1[CH3:12]

참가 물질

5

반응물 3

HCID 885552,3,5-TrimethylanisoleHCID 6451240Aluminum(III) ChlorideHCID 148422765-Nitrothiazole-2-carbonyl chloride

생성물 1

HCID 21481569(4-Methoxy-2,3,6-trimethylphenyl)(5-nitro-1,3-thiazol-2-yl)methanone

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

One gram of 5-nitrothiazole-2-carboxylic acid chloride in 10 ml. of methylene chloride is combined with 850 mg. of 2,3,5-trimethylanisole and then with 1.6 g. of aluminum chloride. After three hours of agitation at room temperature, the reaction mixture is poured on 50 ml. of 1N HCl and extracted with ethyl acetate. After drying of the solution and evaporating the solvent under vacuum, the crystalline residue is recrystallized from methanol/chloroform.

후처리

  1. additionthe reaction mixture is poured on 50 ml
  2. extractionof 1N HCl and extracted with ethyl acetate
  3. customAfter drying of the solution
  4. customevaporating the solvent under vacuum
  5. customthe crystalline residue is recrystallized from methanol/chloroform

출처 및 근거

ORD 기록
ord-2d72e8aae1df4bf88be3a81bd9d3f0bc
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04006241

연결된 노트

불러오는 중…