2-Tert-Butylphenol → 1-tert-Butyl-2-(2,3-epoxypropoxy)benzene

HRID 435849노트

반응식

HRID 435849 반응식
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[OH:11])([CH3:4])([CH3:3])[CH3:2].[CH2:12]([CH:14]1[O:16][CH2:15]1)Cl.[OH-].[K+]>C(O)C.O>[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[O:11][CH2:12][CH:14]1[O:16][CH2:15]1)([CH3:4])([CH3:2])[CH3:3]

참가 물질

6

반응물 3

HCID 69232-Tert-ButylphenolHCID 7835EpichlorohydrinHCID 14797Potassium Hydroxide

생성물 1

HCID 30162201-tert-Butyl-2-(2,3-epoxypropoxy)benzene

시약·촉매·용매 2

HCID 702Ethanol용매2회HCID 962Water용매2회

실험 절차

To a solution of 40 parts of o-t-butylphenol, 75 parts of epichlorhydrin, and 40 parts of ethanol boiling under reflux with stirring was added dropwise over 10 minutes a solution of 17.6 parts of potassium hydroxide dissolved in 66 parts of ethanol and the minimum amount of water. The mixture was stirred and refluxed for 105 minutes, cooled, diluted with water, and well extracted with ether, which was then washed with water, dried over magnesium sulphate, and evaporated to an oil. Distillation at 144° /8 mm afforded 43 parts of 3-(2-t-butylphenoxy)-1,2-epoxypropane as a clear oil.

후처리

  1. stirringThe mixture was stirred
  2. temperaturerefluxed for 105 minutes
  3. temperaturecooled
  4. extractionwell extracted with ether, which
  5. washwas then washed with water
  6. dry with materialdried over magnesium sulphate
  7. customevaporated to an oil
  8. distillationDistillation at 144° /8 mm

출처 및 근거

ORD 기록
ord-2438bd2fcece45639b069c4a2208a2ec
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04006245

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