Formic Acid → N-(3-(dimethylamino)propyl)formamide

HRID 435923

반응식

HRID 435923 반응식
[CH:1]([OH:3])=O.[CH3:4][N:5]([CH2:7][CH2:8][CH2:9][NH2:10])[CH3:6].C1(C)C=CC=CC=1>O>[CH3:4][N:5]([CH3:6])[CH2:7][CH2:8][CH2:9][NH:10][CH:1]=[O:3]

참가 물질

5

반응물 3

HCID 284Formic AcidHCID 1140TolueneHCID 7993N,N-Dimethyl-1,3-propanediamine

생성물 1

HCID 80020N-(3-(dimethylamino)propyl)formamide수율 59%

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

Formic acid (23 g., 0.5 mole), dimethylaminopropylamine (51 g., 0.5 mole) and toluene (50 ml) were azeotroped together with continual removal of water using a Dean and Stark separator until no more water was formed. Toluene was distilled off and the pale yellow residue distilled in vacuo. The colourless liquid product of low smell (N-(3-dimethylaminopropyl)formamide) was obtained in a yield of 59% of theory, b.p. 140° C/15 mm Hg.

후처리

  1. customwas formed
  2. distillationToluene was distilled off
  3. distillationthe pale yellow residue distilled in vacuo

출처 및 근거

ORD 기록
ord-e537d7b8b53e40359f2afc800bf1e2f2
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04007140

연결된 노트

불러오는 중…