Sodium Azide → 3-Aminorifamycin S

HRID 435927

반응식

HRID 435927 반응식
[CH3:1][C:2]1[C:7]2[O:8][C@:9]3([CH3:49])[O:12][CH:13]=[CH:14][C@H:15]([O:47][CH3:48])[C@@H:16]([CH3:46])[C@@H:17]([O:42][C:43]([CH3:45])=[O:44])[C@H:18]([CH3:41])[C@H:19]([OH:40])[C@H:20]([CH3:39])[C@@H:21]([OH:38])[C@@H:22]([CH3:37])[CH:23]=[CH:24][CH:25]=[C:26]([CH3:36])[C:27]([NH:29][C:30]4[C:34](=[O:35])[C:4](=[C:5]([C:32](=[O:33])[CH:31]=4)[C:6]=2[C:10]3=[O:11])[C:3]=1[OH:50])=[O:28].[N-:51]=[N+]=[N-].[Na+]>CN(C)C=O>[CH3:37][C@@H:22]1[C@H:21]([OH:38])[C@@H:20]([CH3:39])[C@@H:19]([OH:40])[C@@H:18]([CH3:41])[C@H:17]([O:42][C:43]([CH3:45])=[O:44])[C@H:16]([CH3:46])[C@@H:15]([O:47][CH3:48])[CH:14]=[CH:13][O:12][C@:9]2([CH3:49])[C:10](=[O:11])[C:6]3[C:7]([O:8]2)=[C:2]([CH3:1])[C:3]([OH:50])=[C:4]2[C:34](=[O:35])[C:30](=[C:31]([NH2:51])[C:32]([C:5]=32)=[O:33])[NH:29][C:27](=[O:28])[C:26]([CH3:36])=[CH:25][CH:24]=[CH:23]1

참가 물질

4

반응물 2

HCID 33557Sodium AzideHCID 6436726Rifamycin S

생성물 1

HCID 128896223-Aminorifamycin S수율 25.5%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

50 g rifamycin S were dissolved in 200 ml dimethyl formamide and added with 9 g sodium azide. After 36 hours at a temperature of +5° C, the reaction mixture was treated as in Example 3, to obtain 13 g 3-amino-rifamycin S identical to that described in Example 3.

후처리

  1. additionthe reaction mixture was treated as in Example 3

출처 및 근거

ORD 기록
ord-f05fa6bfaf3840458238356cf61f0acd
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04007169

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