Hydrochloric Acid → 2-(2-Isopropyl-5-indanyl)propionic acid

HRID 435972

반응식

HRID 435972 반응식
[CH:1]([CH:4]1[CH2:12][C:11]2[C:6](=[CH:7][C:8]([CH:13]([CH3:17])[C:14]([OH:16])=[O:15])=[CH:9][CH:10]=2)[C:5]1=O)([CH3:3])[CH3:2].Cl.O1CCOCC1>O>[CH:1]([CH:4]1[CH2:5][C:6]2[C:11](=[CH:10][CH:9]=[C:8]([CH:13]([CH3:17])[C:14]([OH:16])=[O:15])[CH:7]=2)[CH2:12]1)([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 126278922-(2-Isopropyl-1-oxoindan-6-yl)propionic acid

생성물 1

HCID 687692-(2-Isopropyl-5-indanyl)propionic acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 15g. of 2-(2-isopropyl-1 -oxoindan-6-yl)propionic acid, 40g. of zinc amalgam, 50 ml. of conc. hydrochloride acid, 200 ml. of dioxane and 30 ml. of water was heated under reflux for 15 hours. After completion of the reaction, the reaction mixture was extracted with ether and the ether extract was washed with water and dried over anhydrous sodium sulfate. The solvent was distilled off from the extract and the residue was recrystallized from n-hexane to give 9.5g. of the desired product as colorless crystals of m.p. 90° - 91.5° C.

후처리

  1. temperatureunder reflux for 15 hours
  2. customAfter completion of the reaction
  3. extractionthe reaction mixture was extracted with ether
  4. extractionthe ether extract
  5. washwas washed with water
  6. dry with materialdried over anhydrous sodium sulfate
  7. distillationThe solvent was distilled off from the
  8. extractionextract
  9. customthe residue was recrystallized from n-hexane
  10. customto give 9.5g

출처 및 근거

ORD 기록
ord-679964d845704a9f8f13557841ed8dc5
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04007179

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