Thionyl Chloride → Methyl 1-chloroindan-4-carboxylate

HRID 436157

반응식

HRID 436157 반응식
O[CH:2]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([C:11]([O:13][CH3:14])=[O:12])[C:5]=2[CH2:4][CH2:3]1.S(Cl)([Cl:17])=O>C(Cl)(Cl)Cl>[Cl:17][CH:2]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([C:11]([O:13][CH3:14])=[O:12])[C:5]=2[CH2:4][CH2:3]1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 20310103Methyl 1-hydroxyindan-4-carboxylate

생성물 1

HCID 20310089Methyl 1-chloroindan-4-carboxylate

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

In 6 ml. of chloroform is dissolved 5.7 g. of methyl 1-hydroxyindan-4-carboxylate and, under cooling with ice, the solution is stirred. Then, 3 ml. of thionyl chloride is added dropwise and, after the dropwise addition has been completed, the mixture is further stirred under cooling with ice for one hour. Then, the solvent and the excess thionyl chloride are distilled off under reduced pressure. The residue obtained is purified by column chromatography on silica gel (500 g. silica gel; eluant: chloroform). The procedure gives methyl 1-chloroindan-4-carboxylate as an oily product.

후처리

  1. additionafter the dropwise addition
  2. stirringthe mixture is further stirred
  3. temperatureunder cooling with ice for one hour
  4. distillationThen, the solvent and the excess thionyl chloride are distilled off under reduced pressure
  5. customThe residue obtained
  6. customis purified by column chromatography on silica gel (500 g. silica gel; eluant: chloroform)

출처 및 근거

ORD 기록
ord-2dd858b351e64e139b66392a4ae5f5aa
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04007225

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