Acetic Anhydride → 2-Acetamido-5H-s-triazolo[5,1-a]isoindole

HRID 436195노트

반응식

HRID 436195 반응식
[NH2:1][C:2]1[N:13]=[C:5]2[C:6]3[C:11]([CH2:12][N:4]2[N:3]=1)=[CH:10][CH:9]=[CH:8][CH:7]=3.[C:14](OC(=O)C)(=[O:16])[CH3:15]>C1C=CC=CC=1>[C:14]([NH:1][C:2]1[N:13]=[C:5]2[C:6]3[C:11]([CH2:12][N:4]2[N:3]=1)=[CH:10][CH:9]=[CH:8][CH:7]=3)(=[O:16])[CH3:15]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 214553042-Amino-5H-s-triazolo[5,1-a]isoindole

생성물 1

HCID 214552742-Acetamido-5H-s-triazolo[5,1-a]isoindole

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

2-Amino-5H-s-triazolo[5,1-a]isoindole (12.08 g) and acetic anhydride (8 ml) are boiled for one hour in 150 ml of benzene. After cooling, the solid precipitate is recovered on filter and then is crystallized from ethyl acetate. Yield 14.35 g (97%). M.p. 258-9°C.

후처리

  1. temperatureAfter cooling
  2. customthe solid precipitate is recovered
  3. filtrationon filter
  4. customis crystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-9e37139e3025459c84c5f985bc6dacf2
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04007276

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