Iodoethane → 2-(3-Ethoxyphenyl)-5h-[1,2,4]triazolo[5,1-a]isoindole

HRID 436199노트

반응식

HRID 436199 반응식
[OH:1][C:2]1[CH:3]=[C:4]([C:8]2[N:19]=[C:11]3[C:12]4[C:17]([CH2:18][N:10]3[N:9]=2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH:5]=[CH:6][CH:7]=1.[O-][CH2:21][CH3:22].[Na+].C(I)C>C(O)C>[CH2:21]([O:1][C:2]1[CH:3]=[C:4]([C:8]2[N:19]=[C:11]3[C:12]4[C:17]([CH2:18][N:10]3[N:9]=2)=[CH:16][CH:15]=[CH:14][CH:13]=4)[CH:5]=[CH:6][CH:7]=1)[CH3:22]

참가 물질

5

반응물 3

HCID 6340Iodoethane2회HCID 2723922Sodium ethoxideHCID 21455283HCID 21455283, 화합물

생성물 1

HCID 1344512-(3-Ethoxyphenyl)-5h-[1,2,4]triazolo[5,1-a]isoindole수율 73%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

2-(3-Hydroxyphenyl)-5H-s-triazolo[5,1-a] isoindole (1.25 g, 0.05 mole) is added to 20 ml of ethanol containing one equivalent proportion of sodium ethoxide. To this mixture is added 0.49 ml (0.06 mole) of ethyl iodide in 5 ml of ethanol. After stirring for one hour at room temperature, a further amount of 0.49 ml of ethyl iodide is added. After refluxing for one hour the solvent is distilled off and the residue is washed with water and extracted with dichloromethane. Evaporation of the solvent and crystallization of the residue from ethanol gives 1 g (73%) of the title product, m.p. 166°-7° C.

후처리

  1. temperatureAfter refluxing for one hour the solvent
  2. distillationis distilled off
  3. washthe residue is washed with water
  4. extractionextracted with dichloromethane
  5. customEvaporation of the solvent and crystallization of the residue from ethanol

출처 및 근거

ORD 기록
ord-410221a369704c02b3a1f49c9d41d587
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04007276

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