Hydrochloric Acid → Prostaglandin B2

HRID 436346

반응식

HRID 436346 반응식
[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C@H:6]([OH:25])/[CH:7]=[CH:8]/[C@@H:9]1[C@@H:14]([CH2:15]/[CH:16]=[CH:17]\[CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22])[C:12](=[O:13])[CH2:11][C@H:10]1O.[OH-].[K+].Cl>C(O)C>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][C@H:6]([OH:25])/[CH:7]=[CH:8]/[C:9]1[CH2:10][CH2:11][C:12](=[O:13])[C:14]=1[CH2:15]/[CH:16]=[CH:17]\[CH2:18][CH2:19][CH2:20][C:21]([OH:23])=[O:22]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 5280360Prostaglandin E2

생성물 1

HCID 5280881Prostaglandin B2

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
10 °C

실험 절차

A solution of racemic PGE2 (200 mg.) in 100 ml. of 50% aqueous ethanol containing 10 grams of potassium hydroxide is kept at 25° C. for 10 hours under nitrogen. Then, the solution is cooled to 10° C. and neutralized by addition of 3 normal hydrochloric acid at 10° C. The resulting solution is extracted repeatedly with ethyl acetate, and the combined ethyl acetate extracts are washed with water and then with saturated aqueous sodium chloride solution, dried, and evaporated to give racemic PGB2.

후처리

  1. extractionThe resulting solution is extracted repeatedly with ethyl acetate
  2. washthe combined ethyl acetate extracts are washed with water
  3. dry with materialwith saturated aqueous sodium chloride solution, dried
  4. customevaporated

출처 및 근거

ORD 기록
ord-053d9b68ef704571972be6dc8e6983e5
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04008263

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