4-Nitrophenyl trifluoroacetate → HCID 178524481, 화합물

HRID 436362

반응식

HRID 436362 반응식
[NH:1]1[CH:8]=[C:7]([C:9]([OH:11])=[O:10])[C:5](=[O:6])[NH:4][C:2]1=[O:3].FC(F)(F)C(O[C:17]1[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=1)=O>N1C=CC=CC=1>[OH:3][C:2]1[N:4]=[C:5]([OH:6])[C:7]([C:9]([O:11][C:17]2[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=2)=[O:10])=[CH:8][N:1]=1

참가 물질

4

반응물 2

HCID 695694-Nitrophenyl trifluoroacetateHCID 903011,2,3,4-Tetrahydro-2,4-dioxo-5-pyrimidinecarboxylic acid

생성물 1

HCID 178524481HCID 178524481, 화합물수율 65.3%

시약·촉매·용매 1

HCID 1049Pyridine용매

반응 조건

온도
45 °C

실험 절차

Uracil-5-carboxylic acid (1.0 g) is dissolved in dry pyridine (20 ml) under heating. p-Nitrophenyl trifluroacetate (1.8 g) is added to the solution which is subsequently stirred at 45° C for 30 minutes. Then, the solution is concentrated to dryness under reduced pressure, and the cyrstals thus obtained are washed with chloroform and then acetone to give the active ester, i.e. p-nitrophenyl 2,4-dihydroxypyrimidine-5-carboxylate (1.16 g). M.P. 298°-299° C (decomp.).

후처리

  1. temperatureunder heating
  2. concentrationThen, the solution is concentrated to dryness under reduced pressure
  3. customthe cyrstals thus obtained
  4. washare washed with chloroform

출처 및 근거

ORD 기록
ord-973d09fdd4f848038325b3f993b5ec89
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04008220

연결된 노트

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