Formaldehyde → 2-Phenyl-3-(3-morpholinopropionyl)benzofuran

HRID 436494

반응식

HRID 436494 반응식
[C:1]1([C:7]2[O:8][C:9]3[CH:18]=[CH:17][CH:16]=[CH:15][C:10]=3[C:11]=2[C:12](=[O:14])[CH3:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:19]=O.Cl.[NH:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>C(O)(C)C>[C:1]1([C:7]2[O:8][C:9]3[CH:18]=[CH:17][CH:16]=[CH:15][C:10]=3[C:11]=2[C:12](=[O:14])[CH2:13][CH2:19][N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 712FormaldehydeHCID 197884Morpholine, hydrochloride (1:1)HCID 130247261-(2-Phenylbenzofuran-3-yl)ethanone

생성물 1

HCID 214527432-Phenyl-3-(3-morpholinopropionyl)benzofuran

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

A mixture of 23.6 grams of 2-phenyl-3- acetylbenzofuran, 70 milliliters of isopropanol, 4.2 grams of paraformaldehyde, and 17.3 grams of morpholine hydrochloride were heated under reflux at the boiling point for 12 hours, after which the solvent was evaporated therefrom under vacuum and the residue was triturated with dilute hydrochloric acid and the hydrochloride of the compound named in the heading of this example, which separated in the form of crystals therefrom, was separated from the mixture by suction filtration and dried. In this manner, 23.8 grams of the specified hydrochloride, which had a melting point of 177°-179°C, was obtained.

후처리

  1. temperaturewere heated
  2. temperatureunder reflux at the boiling point for 12 hours
  3. customafter which the solvent was evaporated
  4. customunder vacuum and the residue was triturated with dilute hydrochloric acid
  5. customseparated in the form of crystals
  6. customwas separated from the mixture by suction filtration
  7. customdried
  8. customwas obtained

출처 및 근거

ORD 기록
ord-97fbee31cadf452da5ea122f3924efeb
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04009184

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