Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formaldehyde → 2-Phenyl-3-(3-morpholinopropionyl)benzofuran
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formaldehyde | HCID 712 | — |
| 반응물 | Morpholine, hydrochloride (1:1) | HCID 197884 | — |
| 반응물 | 1-(2-Phenylbenzofuran-3-yl)ethanone | HCID 13024726 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 2-Phenyl-3-(3-morpholinopropionyl)benzofuran | HCID 21452743 | — |
반응 단계
A mixture of 23.6 grams of 2-phenyl-3- acetylbenzofuran, 70 milliliters of isopropanol, 4.2 grams of paraformaldehyde, and 17.3 grams of morpholine hydrochloride were heated under reflux at the boiling point for 12 hours, after which the solvent was evaporated therefrom under vacuum and the residue was triturated with dilute hydrochloric acid and the hydrochloride of the compound named in the heading of this example, which separated in the form of crystals therefrom, was separated from the mixture by suction filtration and dried. In this manner, 23.8 grams of the specified hydrochloride, which had a melting point of 177°-179°C, was obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04009184 |
| 출처 데이터셋 | uspto-grants-1977_02 |
| ORD ID | ord-97fbee31cadf452da5ea122f3924efeb |
| 출처 메모 | uspto-grants-1977_02 |