Water → 4-acetamino-3-methyl-N-(beta-methanesulfonamidoethyl)-N-ethylaniline

HRID 436545

반응식

HRID 436545 반응식
[NH:1]([C:5]1[CH:13]=[CH:12][C:8]([NH:9][CH2:10][CH3:11])=[CH:7][C:6]=1[CH3:14])[C:2]([CH3:4])=[O:3].[CH3:15][S:16]([NH:19][CH2:20][CH2:21]Cl)(=[O:18])=[O:17].C(=O)([O-])O.[Na+].O>CO>[NH:1]([C:5]1[CH:13]=[CH:12][C:8]([N:9]([CH2:21][CH2:20][NH:19][S:16]([CH3:15])(=[O:18])=[O:17])[CH2:10][CH3:11])=[CH:7][C:6]=1[CH3:14])[C:2]([CH3:4])=[O:3]

참가 물질

6

반응물 4

HCID 962WaterHCID 89092N-(2-Chloroethyl)methanesulphonamideHCID 516892Sodium BicarbonateHCID 214528314-Acetamino-3-methyl-N-ethylaniline

생성물 1

HCID 214528344-acetamino-3-methyl-N-(beta-methanesulfonamidoethyl)-N-ethylaniline

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A mixture of 57.6g of 4-acetamino-3-methyl-N-ethylaniline, 52g of βmethanesulfonamidoethyl chloride, 27.7g of sodium hydrogen carbonate, 70g of water and 70ml of methanol were refluxed for 5 hours, and thereafter the methanol was distilled out under reduced pressure. Water was added to the reaction system and an oily product separated out. This oily product was poured into ethyl acetate and cooled to obtain white 4-acetamino-3-methyl-N-(β-methanesulfonamidoethyl)-N-ethylaniline.

후처리

  1. temperaturewere refluxed for 5 hours
  2. distillationthe methanol was distilled out under reduced pressure
  3. additionWater was added to the reaction system
  4. customan oily product separated out
  5. additionThis oily product was poured into ethyl acetate
  6. temperaturecooled

출처 및 근거

ORD 기록
ord-0415ffa5af224365b1f5a0fffd76f923
출처 데이터셋
uspto-grants-1977_02
특허 번호
US04009205

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